1MF, CF Advanced Preclinical Imaging

Up to 5 most important technical / methodological publications (including IF) created by the members of the CzBI team at your facility

Loukotová L, Kučka J, Rabyk M, Höcherl A, Venclíková K, Janoušková O, Páral P, Kolářová V, Heizer T, Šefc L, Štěpánek P, Hrubý M. Thermoresponsive β-glucan-based polymers for bimodal immunoradiotherapy – Are they able to promote the immune system? Journal of Controlled Release. 2017 Dec 28;268:78-91. doi: 10.1016/j.jconrel.2017.10.010. Epub 2017 Oct 12. PMID: 29031896, IF = 7,789  New apprpach to theranostics. Along with brachytherapy isotope an immunostimulating agent is delivered to the tumor. It stimulates immune system and after a primary tumor is cured, subsequent tuor cell inoculation fails to develop a new tumor.

Horak D, Kostiv U, Lobaz V, Kucka J, Švec P, Sedláček O, Hruby M, Janoušková O, Francová P, Kolářová V, Šefc L. A simple neridronate-based surface coating strategy for upconversion nanoparticles: Highly colloidally stable 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles for multimodal in vivo tissue imaging. Nanoscale, 2017 Nov 9;9(43):16680-16688. doi: 10.1039/c7nr05456d. PMID: 29067394, IF = 7,367. The description of the new upconversion nanoparticles for optical imaging. These particles were successfully used for in vivo imaging.

Tomáš Etrych, Lenka Daumová, Eva Pokorná, Diana Tušková, Ondřej Lidický, Věra Kolářová, Jan Pankrác, Luděk Šefc, Petr Chytil, Pavel Klener. Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging. J Control Release. 2018 Sep 22;289:44-55. doi: 10.1016/j.jconrel.2018.09.018. [Epub ahead of print], PMID: 30248447 IF=7,877 Development and testing of novel theranostic nanoparticles effective for optical whole body imaging and treatment of human lymphomas in patient-derived xenografted immunodeficient mice (PDX mice).

Vetrik M, Mattova J, Mackova H, Kucka J, Pouckova P, Kukackova O, Brus J, Eigner-Henke S, Sedlacek O, Sefc L, Stepanek P, Hruby M. Biopolymer strategy for the treatment of Wilson's disease. J Control Release. 2018 Feb 1;273:131-138. doi: 10.1016/j.jconrel.2018.01.026. [Epub ahead of print] PMID: 29407674. IF=7,877. The new approach to avoid copper intoxication in patients with Wilson’s disease has been developped and successfully tested in laboratory rats. The copper chelators that are not resorbed in the intestinal tract block copper intaake without side effects.

Faltusová K, Szikszai K, Molík M, Linhartová J, Páral P, Šefc L, Savvulidi F, Nečas E. Stem Cell Defect in Ubiquitin-Green Fluorescent Protein Mice Facilitates Engraftment of Lymphoid-Primed Hematopoietic Stem Cells. Stem Cells. 2018 Aug;36(8):1237-1248. doi: 10.1002/stem.2828. Epub 2018 Apr 15. PMID: 29603838, IF=5,599. Description and explanation of the hematopoietic defect caused by transgenic genome modification in mice with GFP reporter gene. These mice have a competent seemingly normal hematopoiesis but it is inferior and outcompeted when grafted with normal wild-type bone marrow. This defect is predominantly in lymphoid lineages.

BIOCEV, CF Imaging Methods

Up to 5 core publications recommended in MEDLINE format (including IF) produced by facility users

Allolio, C. et al. Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore. Proc. Natl. Acad. Sci. (2018). doi:10.1073/pnas.1811520115, IF 9.504

Bajzikova, M. et al. Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metab. 29, 1–18 (2018). IF 20.565

Kazamia, E. et al. Endocytosis-mediated siderophore uptake as a strategy for Fe acquisition in diatoms. Sci. Adv. 4, eaar4536 (2018). IF 11.511

Koudelkova, L. et al. Novel FRET-Based Src Biosensor Reveals Mechanisms of Src Activation and Its Dynamics in Focal Adhesions. Cell Chem. Biol. 1–14 (2018). IF 5.592

Rada, P., Makki, A., Žárský, V. & Tachezy, J. Targeting of tail-anchored proteins to Trichomonas vaginalis hydrogenosomes. Mol. Microbiol. (2018). doi:10.1111/mmi.14175, IF 3.816

Up to 5 most important technical / methodological publications (including IF) created by the members of the CzBI team at your facility

Agarwal, K. & Macháň, R. Multiple signal classification algorithm for super-resolution fluorescence microscopy. Nat. Commun. 7, (2016). IF 12.124

Ma, Y. et al. An intermolecular FRET sensor detects the dynamics of T cell receptor clustering. Nat. Commun. (2017). doi:10.1038/ncomms15100. IF 12.353

Lukeš, T. et al. Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging. Nat. Commun. 8, (2017). IF 12.353

Nicovich, P. R., Kwiatek, J. M., Ma, Y., Benda, A. & Gaus, K. FSCS Reveals the Complexity of Lipid Domain Dynamics in the Plasma Membrane of Live Cells. Biophys. J. 114, 2855–2864 (2018). IF 3.495

Olšinová, M. et al. Roughness of transmembrane helices reduces lipid membrane dynamics. iScience 10, 87–97 (2018). IF - new journal

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