Loukotová L, Kučka J, Rabyk M, Höcherl A, Venclíková K, Janoušková O, Páral P, Kolářová V, Heizer T, Šefc L, Štěpánek P, Hrubý M. Thermoresponsive β-glucan-based polymers for bimodal immunoradiotherapy – Are they able to promote the immune system? Journal of Controlled Release. 2017 Dec 28;268:78-91. doi: 10.1016/j.jconrel.2017.10.010. Epub 2017 Oct 12. PMID: 29031896, IF = 7,789 New apprpach to theranostics. Along with brachytherapy isotope an immunostimulating agent is delivered to the tumor. It stimulates immune system and after a primary tumor is cured, subsequent tuor cell inoculation fails to develop a new tumor.
Horak D, Kostiv U, Lobaz V, Kucka J, Švec P, Sedláček O, Hruby M, Janoušková O, Francová P, Kolářová V, Šefc L. A simple neridronate-based surface coating strategy for upconversion nanoparticles: Highly colloidally stable 125I-radiolabeled NaYF4:Yb3+/Er3+@PEG nanoparticles for multimodal in vivo tissue imaging. Nanoscale, 2017 Nov 9;9(43):16680-16688. doi: 10.1039/c7nr05456d. PMID: 29067394, IF = 7,367. The description of the new upconversion nanoparticles for optical imaging. These particles were successfully used for in vivo imaging.
Tomáš Etrych, Lenka Daumová, Eva Pokorná, Diana Tušková, Ondřej Lidický, Věra Kolářová, Jan Pankrác, Luděk Šefc, Petr Chytil, Pavel Klener. Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging. J Control Release. 2018 Sep 22;289:44-55. doi: 10.1016/j.jconrel.2018.09.018. [Epub ahead of print], PMID: 30248447 IF=7,877 Development and testing of novel theranostic nanoparticles effective for optical whole body imaging and treatment of human lymphomas in patient-derived xenografted immunodeficient mice (PDX mice).
Vetrik M, Mattova J, Mackova H, Kucka J, Pouckova P, Kukackova O, Brus J, Eigner-Henke S, Sedlacek O, Sefc L, Stepanek P, Hruby M. Biopolymer strategy for the treatment of Wilson's disease. J Control Release. 2018 Feb 1;273:131-138. doi: 10.1016/j.jconrel.2018.01.026. [Epub ahead of print] PMID: 29407674. IF=7,877. The new approach to avoid copper intoxication in patients with Wilson’s disease has been developped and successfully tested in laboratory rats. The copper chelators that are not resorbed in the intestinal tract block copper intaake without side effects.
Faltusová K, Szikszai K, Molík M, Linhartová J, Páral P, Šefc L, Savvulidi F, Nečas E. Stem Cell Defect in Ubiquitin-Green Fluorescent Protein Mice Facilitates Engraftment of Lymphoid-Primed Hematopoietic Stem Cells. Stem Cells. 2018 Aug;36(8):1237-1248. doi: 10.1002/stem.2828. Epub 2018 Apr 15. PMID: 29603838, IF=5,599. Description and explanation of the hematopoietic defect caused by transgenic genome modification in mice with GFP reporter gene. These mice have a competent seemingly normal hematopoiesis but it is inferior and outcompeted when grafted with normal wild-type bone marrow. This defect is predominantly in lymphoid lineages.
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7 - 8 October 2020, Multifunctional Centre Chateau Lednice, Czech Republic